VERIFICATION OF BLOOD-BRAIN BARRIER DISRUPTION BASED ON THE CLINICAL VALIDATION PLATFORM USING A RAT MODEL WITH HUMAN SKULL

Verification of Blood-Brain Barrier Disruption Based on the Clinical Validation Platform Using a Rat Model with Human Skull

Methods to improve drug delivery efficiency through blood-brain barrier disruption (BBBD) based on microbubbles and focused ultrasound (FUS) are continuously being studied.However, most studies are being conducted in preclinical trial environments using small animals.The use of the human skull shows differences between the clinical and preclinical

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Impact of Plant-Beneficial Bacterial Inocula on the Resident Bacteriome: Current Knowledge and Future Perspectives

The inoculation of plant growth-promoting bacteria (PGPB) as biofertilizers is one of the most efficient and Night Lights sustainable strategies of rhizosphere manipulation leading to increased plant biomass and yield and improved plant health, as well as the ameliorated nutritional value of fruits and edible seeds.During the last decades, exciting

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A Method of Images to Study Plate-Impact-Induced Cavitation in Aluminum through Molecular Dynamics Simulation

The tensile stress generated by the superposition of two reflection waves in the target plays a critical role in explaining plate-impact-induced spalling.A method of images is proposed to simulate the physical process of wave superposition and this method is applied in order to study the cavitation mechanism in single-crystal Al through molecular d

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Chirality transmission in macromolecular domains

Chiral communication Relish can propagate in secondary structures within the effective intermolecular force (IMF) range but it is not known whether long-range chiral communication exists between tertiary peptide structures.Here, the authors use single-molecule force spectroscopy to investigate chiral interaction between DNA duplexes/triplexes Easte

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A case report on secondary mesentero-axial gastric volvulus

Mesentero-axial gastric volvulus is a rare presentation to a surgical casualty unit with sinister Bumper Guards and Accessories complications and significant mortality and morbidity.Clinical assessment should be done with high suspicion in the case of an associated anatomical defect.Accurate diagnosis and timely intervention would drastically reduc

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